Zoloft 100mg*Pfizer 30 tabs
Basic substance : Sertraline hydrochloride
Package : 100mg/tab * 30 tabs
Category : ANTIDEPRESSANTS
Zoloft (Sertraline) is an inexpensive drug used to treat depression.
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Zoloft (sertraline) is an SSRI (selective serotonin reuptake inhibitors) antidepressant prescribed for the treatment of depression, obsessive compulsive disorder (OCD), panic disorder, posttraumatic stress disorder (PTSD), social anxiety disorder, and premenstrual dysphoric disorder (PMDD).
The mode of action of sertraline hydrochloride is related to its ability to inhibit the reuptake of serotonin by neurons. It acts only weakly on the neuronal reuptake of norepinephrine and dopamine. In humans, therapeutic doses of sertraline hydrochloride inhibit the reuptake of serotonin in platelets.
Like most effective antidepressants, sertraline hydrochloride downregulates brain norepinephrine and serotonin receptors in animals. Sertralin hydrochloride did not show significant affinity for adrenergic (alpha1, alpha2 and beta), cholinergic, dopaminergic, histaminergic, serotoninergic (5- HT1A, 5-HT1B and 5-HT2) and finally, for those of GABA and Benzodiazepine.
Sertraline should be given once a day, morning or evening.
Sertraline capsules should be given during the meal.
In patients not responding to a 50 mg dose, a dose increase is possible. Dose changes should be made in increments of 50 mg at intervals of at least one week to a maximum of 200mg/day. Dose changes should not be made more than once a week, given the elimination half-life of sertraline which is 24 hours.
The therapeutic effect can manifest itself within 7 days. However, longer periods are usually required to achieve a therapeutic response, particularly for TOCs.
Longer-term treatment may also be appropriate for preventing recurrence of major depressive episodes (MDEs). In most cases, the recommended dose for preventing recurrence of EDM is the same as that used during the current episode. Depressive patients should be treated for a sufficiently long period of at least 6 months to ensure the disappearance of symptoms.
- Panic disorder and OCD
Any ongoing treatment in panic disorder or OCD should be re-evaluated regularly as relapse prevention has not been demonstrated in these disorders.
Children and adolescents with obsessive compulsive disorder
Between 13 and 17 years old: initial dose of 50 mg once a day.
Between 6 and 12 years old: initial dose of 25 mg once a day. The dose can be increased up to 50 mg once a day after a week.
In case of insufficient response, a secondary increase of the dose is possible in increments of 50 mg over a period of several weeks if necessary. The maximum dose is 200 mg per day.
However, we must take into account the generally lower weight of children compared to that of adults in case of a dose increase above 50 mg. Dose changes should not be made at intervals of less than one week.
Efficacy is not demonstrated in the major depressive disorder of the child.
No data is available for children under 6 years of age (see also Warnings and precautions for use).
- Use in the elderly
In the elderly, the dose should be carefully adjusted because of the increased risk of hyponatremia (see Warnings and Precautions).
Contraindications: when not to use this medicine?
Sertraline hypersensitivity Severe hepatic impairment Uncontrolled epilepsy Children under 6 years of age No effective female contraception Hydro-electrolytic imbalance Galactose intolerance Glucose malabsorption syndrome
Withdrawal symptoms :
Patients who are on ZOLOFT therapy should NOT stop abruptly because of the risk of withdrawal symptoms. It is therefore recommended, when the physician decides to stop treatment with an SSRI or other recent antidepressant, to gradually reduce the dose, instead of stopping treatment abruptly.
Stop treatment with ZOLOFT
When ZOLOFT therapy is discontinued, patients should be closely monitored for any symptoms that may be associated with discontinuation of treatment (eg, dizziness, abnormal dreams, sensory disturbances – including paresthesia, and feeling of electric shock – agitation, anxiety, fatigue, confusion, headache, tremors, nausea, vomiting and sweating, or other symptoms that may be of clinical importance (see ADVERSE REACTIONS). It is recommended to gradually reduce the dose over several weeks, instead of abruptly stopping treatment, if possible. If intolerable symptoms occur after a dose reduction or at the end of treatment, adjust the dose based on the patient’s clinical response (see ADVERSE REACTIONS and DOSAGE AND DOSAGE).
Side effects :
sleep problems (insomnia)
changes in appetite
decreased sex drive
difficulty having an orgasm
dry mouth, and
Tell your doctor if you have serious side effects of Zoloft including:
very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, feeling like you might pass out;
agitation, hallucinations, fever, overactive reflexes, tremors;
nausea, vomiting, loss of appetite, feeling unsteady, loss of coordination;
trouble concentrating, memory problems, weakness, fainting, seizure, shallow breathing, or breathing that stops.