Tramadol 100mg /2ml *Hydrochloride Injection


Tramadol 100mg /2ml *Hydrochloride Injection

Manufactured : Adiuvo
Basic substance : Tramadol Hydrochloride
Package : 2ml vial x 10 
Category : PAIN KILLER

Tramadol is used in the treatment of moderate to severe pain in adults and adolescents over the age of 15 years.



Tramadol 100mg /2ml *Hydrochloride Injection

Tramadol 100mg /2ml – the active substance in Tramadol Hydrochloride  is an analgesic (pain-calming substance) that belongs to the class of opioids (such as morphine). It acts on the central nervous system and relieves pain by acting on specific nerve cells in the spinal cord and brain.

It is indicated for the treatment of moderate to severe pain in adults and adolescents over 15 years of age.

Tramadol 100mg /2ml should not be administered for longer than absolutely necessary. If long-term pain management with this drug is necessary, given the nature and severity of the disease, careful and regular monitoring (including therapeutic breaks, if necessary) to to check whether and to what extent continuation of treatment is necessary.


Dosage :

Tramadol 50mg/ml Solution for Injection should not be administered for longer than absolutely necessary. If long-term pain treatment with Tramadol 50mg/ml Solution for Injection is necessary in view of the nature and severity of the illness, then careful regular monitoring should be carried out (if necessary with breaks in treatment) to establish whether, and to what extent, further treatment is necessary.

The dose should be adjusted to the intensity of the pain and the sensitivity of the individual patient. The lowest effective dose for analgesia should generally be selected. The total daily dose of 400mg tramadol hydrochloride should not be exceeded, except in special clinical circumstances.

The Tramadol 100mg /2ml solution is for parenteral injection either intramuscularly, by slow intravenous injection or diluted in solution (see Section 6.6 Special instructions for use and handling) for administration by infusion or patient controlled analgesia.

Adults and children 12 years and over:

The usual dose is 50mg or 100mg 4 to 6 hourly by either intramuscular or intravenous routes. Intravenous injections must be given slowly over 2–3 minutes. The dose should be adjusted according to the severity of the pain and the response.

For post-operative pain, an initial bolus of 100mg is administered. During the 60 minutes following the initial bolus, further doses of 50mg may be given every 10-20 minutes, up to a total dose of 250mg including the initial bolus. Subsequent doses should be 50mg or 100mg 4- 6 hourly up to a total daily dose of 400mg.

Geriatric patients

A dose adjustment is not usually necessary in patients up to 75 years without clinically manifest hepatic or renal insufficiency. In elderly patients over 75 years elimination may be prolonged. Therefore, if necessary the dosage interval is to be extended according to the patient’s requirements.

Renal insufficiency/dialysis and hepatic impairment

In patients with renal and/or hepatic insufficiency the elimination of tramadol is delayed. In these patients prolongation of the dosage intervals should be carefully considered according to the patient’s requirements.


Side effects : 

Get emergency medical help if you have signs of an allergic reaction to tramadol (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Like other narcotic medicines, tramadol can slow your breathing. Death may occur if breathing becomes too weak.

A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Call your doctor at once if you have:

noisy breathing, sighing, shallow breathing;

a slow heart rate or weak pulse;

a light-headed feeling, like you might pass out;

seizure (convulsions);

missed menstrual periods;

impotence, sexual problems, loss of interest in sex; or

nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Serious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.

Long-term use of opioid medication may affect fertility (ability to have children) for men or women. It is not known whether opioid effects on fertility are permanent.

Common tramadol side effects may include:

headache, dizziness, drowsiness, tired feeling;

constipation, diarrhea, nausea, vomiting, stomach pain;

feeling nervous or anxious;

itching, sweating, flushing (warmth, redness, or tingly feeling;.

dry mouth


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